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Nationwide study into COVID-19 infection, reinfection, immunity backed by philanthropic investment: News at IU: Indiana University

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BLOOMINGTON, Ind. — Researchers from the Indiana University School of Public Health-Bloomington and the Department of Biology within the IU Bloomington College of Arts and Sciences will lead a serious nationwide examine on COVID-19 an infection and reinfection, and the potential for long-term immunity to SARS-CoV-2.

Backed by a philanthropic funding of $12.5 million from Jack Dorsey’s #StartSmall Initiative and the Chase and Stephanie Coleman Basis, the Aegis Research will run via 2021 and can embrace 2,100 individuals from a number of U.S. areas, possible together with Chicago, New York, Bloomington and Indianapolis.

“Indiana College is extraordinarily grateful for the beneficiant monetary help for — and alternative to guide — this landmark public well being examine,” IU President Michael A. McRobbie stated. “Via this examine, main public well being researchers from IU and across the nation will search to seize vital details about the evolution of COVID-19 and reply the important thing query of how lengthy the immune system can defend people from the virus after they’ve been contaminated. As such, this examine guarantees to have vital implications for the effectiveness and longevity of a vaccine for the virus.”

IU College of Public Well being-Bloomington Dean David B. Allison and Kevin C. Maki, adjunct professor within the faculty’s Division of Utilized Well being Science, will function co-principal investigators of the Aegis Research. Further IU researchers will embrace College of Public Well being college members Jon Macy, Molly Rosenberg, Christina Ludema and Stephanie Dickinson, and John Patton from the Division of Biology.

“The Aegis Research features a dream staff of remarkable investigators, and I’m assured that, collectively, we’ll have the ability to unlock a few of the mysteries round COVID-19 immunity,” Allison stated. “Primarily, we wish to decide whether or not prior SARS-CoV-2 an infection, the event of antibodies and subsequent restoration from COVID-19 can forestall or, maybe, mitigate the reemergence of COVID-19. And, if reinfection does happen, is it kind of extreme than the preliminary an infection?

“I’m humbled by and deeply grateful for the arrogance that our donors’ generosity displays and for the privilege of co-leading this important public well being mission.”

Allison stated that definitively answering these basic questions may inform vaccine improvement and allocation, organizational and governmental insurance policies for secure reopening and long-term operation, and even particular person decisions about what constitutes secure behaviors.

“Indiana College is dedicated to working with the very best tutorial scientists within the nation to search out solutions to the massive questions dealing with our nation on this public well being emergency,” IU Bloomington Provost and Government Vice President Lauren Robel stated. “Working with colleagues across the nation, IU’s excellent scientists are well-positioned to make fast progress on the vital questions on COVID immunity.”

The multi-institutional examine’s staff of investigators additionally will embrace David Watkins of George Washington College and Stanley Perlman of the College of Iowa, in addition to Sema4 CEO Eric Schadt, Alessandro Sette of the La Jolla Institute for Immunology, Peter Attia of Attia Medical, and Harvey Fineberg, president of the Gordon and Betty Moore Basis. Stanford College’s John Ioannidis and Eran Bendavid, and New York College’s Danielle Ompad, will function consultants.

Set to start earlier than the top of the calendar 12 months, the possible cohort examine seeks to enroll adults with and with out prior SARS-CoV-2 an infection who dwell in a number of U.S. areas the place publicity to an infection threat seems elevated. The Aegis Research will embrace follow-up of not less than one 12 months, and preliminary outcomes are anticipated in 2021.

IU Analysis

Indiana College’s world-class researchers have pushed innovation and artistic initiatives that matter for 200 years. From curing testicular most cancers to collaborating with NASA to seek for life on Mars, IU has earned its popularity as a world-class analysis establishment. Supported by $854 million final 12 months from our companions, IU researchers are constructing collaborations and uncovering new options that enhance lives in Indiana and across the globe.

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