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Nationwide study into COVID-19 infection, reinfection, immunity backed by philanthropic investment

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Researchers from the Indiana University School of Public Health-Bloomington and the Department of Biology within the IU Bloomington College of Arts and Sciences will lead a significant nationwide research on COVID-19 an infection and reinfection, and the potential for long-term immunity to SARS-CoV-2.

Backed by a philanthropic funding of $12.5 million from Jack Dorsey’s #StartSmall Initiative and the Chase and Stephanie Coleman Basis, the Aegis Examine will run by 2021 and can embrace 2,100 contributors from a number of U.S. places, probably together with Chicago, New York, Bloomington and Indianapolis.

“Indiana College is extraordinarily grateful for the beneficiant monetary help for — and alternative to guide — this landmark public well being research,” IU President Michael A. McRobbie mentioned. “By way of this research, main public well being researchers from IU and across the nation will search to seize crucial details about the evolution of COVID-19 and reply the important thing query of how lengthy the immune system can shield people from the virus after they’ve been contaminated. As such, this research guarantees to have essential implications for the effectiveness and longevity of a vaccine for the virus.”

IU Faculty of Public Well being-Bloomington Dean David B. Allison and Kevin C. Maki, adjunct professor within the faculty’s Division of Utilized Well being Science, will function co-principal investigators of the Aegis Examine. Extra IU researchers will embrace Faculty of Public Well being school members Jon Macy, Molly Rosenberg, Christina Ludema and Stephanie Dickinson, and John Patton from the Division of Biology.

“The Aegis Examine features a dream workforce of outstanding investigators, and I’m assured that, collectively, we’ll be capable to unlock among the mysteries round COVID-19 immunity,” Allison mentioned. “Primarily, we need to decide whether or not prior SARS-CoV-2 an infection, the event of antibodies and subsequent restoration from COVID-19 can stop or, maybe, mitigate the reemergence of COVID-19. And, if reinfection does happen, is it kind of extreme than the preliminary an infection?

David B. Allison
David B. Allison

“I’m humbled by and deeply grateful for the arrogance that our donors’ generosity displays and for the privilege of co-leading this important public well being mission.”

Allison mentioned that definitively answering these elementary questions might inform vaccine improvement and allocation, organizational and governmental insurance policies for protected reopening and long-term operation, and even particular person decisions about what constitutes protected behaviors.

“Indiana College is dedicated to working with the most effective tutorial scientists within the nation to seek out solutions to the massive questions going through our nation on this public well being emergency,” IU Bloomington Provost and Government Vice President Lauren Robel mentioned. “Working with colleagues across the nation, IU’s excellent scientists are well-positioned to make fast progress on the essential questions on COVID immunity.”

The multi-institutional research’s workforce of investigators additionally will embrace David Watkins of George Washington College and Stanley Perlman of the College of Iowa, in addition to Sema4 CEO Eric Schadt, Alessandro Sette of the La Jolla Institute for Immunology, Peter Attia of Attia Medical, and Harvey Fineberg, president of the Gordon and Betty Moore Basis. Stanford College’s John Ioannidis and Eran Bendavid, and New York College’s Danielle Ompad, will function consultants.

Set to start earlier than the top of the calendar yr, the potential cohort research seeks to enroll adults with and with out prior SARS-CoV-2 an infection who dwell in a number of U.S. places the place publicity to an infection threat seems elevated. The Aegis Examine will embrace follow-up of a minimum of one yr, and preliminary outcomes are anticipated in 2021.

/Public Launch. The fabric on this public launch comes from the originating group and could also be of a point-in-time nature, edited for readability, fashion and size. View in full here.

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